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name: pubmed-trends description: > Query PubMed publication trends via x402 micropayments to identify emerging research fields, compare therapeutic areas, detect publication spikes, find key papers, and profile authors. Use when analyzing biotech/pharma landscapes, writing grant applications, evaluating drug targets, or researching scientific trends. Requires the x402 skill from coinbase/agentic-wallet-skills for payment commands.

PubMed Trends API

Pay-per-query research intelligence from 37M+ PubMed articles. No API keys, no subscriptions — just USDC micropayments on Base via x402.

Base URL: https://pubmed.sekgen.xyz

Companion skill: Install x402 from coinbase/agentic-wallet-skills for payment commands.

Endpoints

GET /api/v1/snapshot — $0.01

Single-year publication count. Cheapest option for quick lookups.

| Parameter | Required | Default | Description | |-----------|----------|---------|-------------| | query | Yes | — | PubMed search query | | year | No | current year | Year to query |

awal x402 pay 'https://pubmed.sekgen.xyz/api/v1/snapshot?query=CRISPR&year=2025'

Returns count, total_pubmed, proportion (share of all PubMed articles).

GET /api/v1/trends — $0.01

Year-by-year publication counts with growth analytics over a range.

| Parameter | Required | Default | Description | |-----------|----------|---------|-------------| | query | Yes | — | PubMed search query | | start_year | No | current - 10 | First year | | end_year | No | current year | Last year | | source | No | pubmed | pubmed or openalex |

awal x402 pay 'https://pubmed.sekgen.xyz/api/v1/trends?query=GLP-1+agonist&start_year=2015'

Returns yearly count, yoy_growth, plus analytics: cagr, trend_direction (growing/declining/stable/emerging), peak_year, acceleration.

GET /api/v1/compare — $0.02

Compare publication trends across 2–5 search terms. Identifies which field is growing fastest and detects crossover points.

| Parameter | Required | Default | Description | |-----------|----------|---------|-------------| | terms | Yes | — | Comma-separated search terms (2–5) | | start_year | No | current - 10 | First year | | end_year | No | current year | Last year | | source | No | pubmed | pubmed or openalex |

awal x402 pay 'https://pubmed.sekgen.xyz/api/v1/compare?terms=CAR-T,bispecific+antibodies,antibody+drug+conjugate'

Returns per-term series with cagr and trend_direction, plus ranking_by_growth and crossover_years (when one term overtook another).

GET /api/v1/pulse — $0.02

Real-time publication pulse with 7d/30d/90d windows and year-over-year change.

| Parameter | Required | Default | Description | |-----------|----------|---------|-------------| | query | Yes | — | PubMed search query |

awal x402 pay 'https://pubmed.sekgen.xyz/api/v1/pulse?query=prime+editing'

Returns current and year_ago counts for 7d/30d/90d windows, plus change (fractional, e.g. 0.35 = 35% increase YoY).

GET /api/v1/keypapers — $0.03

Scored key papers for a query within a time window. Papers are ranked by a composite score based on journal prestige, publication type, MeSH relevance, and citation impact (via OpenAlex).

| Parameter | Required | Default | Description | |-----------|----------|---------|-------------| | query | Yes | — | PubMed search query | | start_year | No | current - 5 | First year | | end_year | No | current year | Last year |

awal x402 pay 'https://pubmed.sekgen.xyz/api/v1/keypapers?query=base+editing&start_year=2023&end_year=2025'

Returns scored papers with pmid, title, journal, pub_year, pub_type, score, score_breakdown (top_journal, review_or_trial, mesh_major_topic, multi_strategy_hit, relevance_rank, citation_impact), cited_by_count, fwci (field-weighted citation impact), open_access status, and authors_enriched (name, institution, country).

GET /api/v1/digest — $0.08

Full research digest combining scored key papers, MeSH term landscape, and frequent authors. The most comprehensive single-call endpoint.

| Parameter | Required | Default | Description | |-----------|----------|---------|-------------| | query | Yes | — | PubMed search query | | start_year | No | current - 5 | First year | | end_year | No | current year | Last year |

awal x402 pay 'https://pubmed.sekgen.xyz/api/v1/digest?query=NF2+schwannomatosis+treatment&start_year=2022&end_year=2025'

Returns everything from /keypapers plus mesh_terms (array of MeSH descriptors across the result set) and authors (recurring authors with appearance counts).

GET /api/v1/hottest-weekly — $0.05

Hottest topics in a category ranked by weekly spike ratio (last 7d vs 30d average). Use category for PubMed curated terms (default) or topic + source=openalex for free-text search.

| Parameter | Required | Default | Description | |-----------|----------|---------|-------------| | category | Yes* | — | See categories below | | topic | Yes* | — | Free-text topic (when source=openalex) | | source | No | pubmed | pubmed or openalex |

*One of category or topic required depending on source.

awal x402 pay 'https://pubmed.sekgen.xyz/api/v1/hottest-weekly?category=oncology'
awal x402 pay 'https://pubmed.sekgen.xyz/api/v1/hottest-weekly?topic=microbiome&source=openalex'

Returns topics sorted by spike_ratio. Values >1.0 mean more activity than usual this week.

GET /api/v1/emerging — $0.05

Scan a category for topics with accelerating publication rates. Use category for PubMed curated terms (default) or topic + source=openalex for free-text search.

| Parameter | Required | Default | Description | |-----------|----------|---------|-------------| | category | Yes* | — | See categories below | | topic | Yes* | — | Free-text topic (when source=openalex) | | source | No | pubmed | pubmed or openalex | | window_years | No | 3 | Years to evaluate growth | | min_growth_rate | No | 0.3 | Minimum CAGR threshold (0.3 = 30%) | | limit | No | 10 | Max results |

*One of category or topic required depending on source.

awal x402 pay 'https://pubmed.sekgen.xyz/api/v1/emerging?category=gene+therapy&min_growth_rate=0.5'
awal x402 pay 'https://pubmed.sekgen.xyz/api/v1/emerging?topic=CRISPR&source=openalex'

Returns topics meeting the growth threshold, sorted by recent_cagr.

GET /api/v1/trending-subtopics — $0.05

Discover which sub-topics within a research field are growing fastest. Uses OpenAlex topic breakdown over a multi-year window.

| Parameter | Required | Default | Description | |-----------|----------|---------|-------------| | query | Yes | — | Research field to decompose | | window | No | 3 | Window size in years (2–5) | | limit | No | 10 | Max results (1–25) |

awal x402 pay 'https://pubmed.sekgen.xyz/api/v1/trending-subtopics?query=ulcerative+colitis&window=3'

Returns sub-topics with topic_id, topic_name, per-year counts, cagr, trend_direction, latest_year_count, and growth_score.

GET /api/v1/explore — $0.10

Discover interesting research signals. Two modes:

1. With topics param — OpenAlex multi-domain scan: searches topics, computes spike_ratio x CAGR, ranks by explore_score.
2. Without topics — D1 MeSH anomaly detection: z-score anomalies from stored baselines.

| Parameter | Required | Default | Description | |-----------|----------|---------|-------------| | topics | No | — | Comma-separated research topics to scan (max 4) | | limit | No | 5 | Max results (1–20) | | min_z_score | No | 2.0 | Minimum z-score for anomaly mode (without topics) | | days | No | 7 | Lookback days for anomaly mode (1–30, without topics) |

awal x402 pay 'https://pubmed.sekgen.xyz/api/v1/explore?topics=neurodegeneration,epigenetics&limit=5'
awal x402 pay 'https://pubmed.sekgen.xyz/api/v1/explore'

Returns ranked results with explore_score, spike_ratio, cagr_3y, trend_direction, and latest_year_count.

GET /api/v1/author — $0.02

Author analytics profile powered by OpenAlex. Returns citation metrics, institutional affiliation, and publication trajectory.

| Parameter | Required | Default | Description | |-----------|----------|---------|-------------| | name | Yes* | — | Author name to look up | | orcid | Yes* | — | ORCID identifier (alternative to name) |

*One of name or orcid required.

awal x402 pay 'https://pubmed.sekgen.xyz/api/v1/author?name=David+Liu'
awal x402 pay 'https://pubmed.sekgen.xyz/api/v1/author?orcid=0000-0001-8277-943X'

Returns name, orcid, works_count, cited_by_count, h_index, i10_index, current_institution (name, country), top_topics, counts_by_year (works, cited_by per year).

Categories

Used by /hottest-weekly and /emerging (PubMed mode):

• oncology — CAR-T, bispecific antibodies, ADCs, checkpoint inhibitors, liquid biopsy, KRAS inhibitors, PARP inhibitors, radiopharmaceuticals, cancer vaccines, spatial transcriptomics
• neuroscience — anti-amyloid antibodies, brain-computer interfaces, psychedelic therapy, GLP-1 neurodegeneration, antisense oligonucleotides, deep brain stimulation
• immunology — mRNA vaccines, CAR-T autoimmune, JAK inhibitors, regulatory T cells, microbiome immunotherapy, complement inhibitors
• gene therapy — CRISPR, base editing, prime editing, AAV gene therapy, lipid nanoparticle mRNA, epigenome editing, RNA interference
• cardiology — PCSK9 inhibitors, SGLT2 inhibitors, cardiac gene therapy, lipoprotein(a) inhibitors, AI cardiac imaging, wearable ECG

Free Endpoints

These do not require payment:

• GET / — Service info and pricing
• GET /health — Health check
• GET /docs — Interactive documentation (HTML, or Markdown with Accept: text/markdown)
• GET /llms.txt — Machine-readable documentation

Example Workflows

Quick fact check ($0.01):

"How much CRISPR research was published in 2025?"

awal x402 pay 'https://pubmed.sekgen.xyz/api/v1/snapshot?query=CRISPR&year=2025'

Technology race ($0.02):

"Is base editing overtaking traditional CRISPR?"

awal x402 pay 'https://pubmed.sekgen.xyz/api/v1/compare?terms=CRISPR+gene+editing,base+editing,prime+editing&start_year=2018'

Weekly research briefing ($0.10):

"What's spiking in oncology and neuroscience right now?"

awal x402 pay 'https://pubmed.sekgen.xyz/api/v1/hottest-weekly?category=oncology'
awal x402 pay 'https://pubmed.sekgen.xyz/api/v1/hottest-weekly?category=neuroscience'

Drug target validation ($0.03):

"Is GLP-1 for neurodegeneration actually gaining traction?"

awal x402 pay 'https://pubmed.sekgen.xyz/api/v1/trends?query=GLP-1+agonist+neurodegeneration&start_year=2018'
awal x402 pay 'https://pubmed.sekgen.xyz/api/v1/pulse?query=GLP-1+agonist+neurodegeneration'

Deep dive into a disease area ($0.13):

"What are the key papers and sub-topics for NF2 schwannoma treatment?"

awal x402 pay 'https://pubmed.sekgen.xyz/api/v1/keypapers?query=NF2+schwannoma+treatment&start_year=2022&end_year=2025'
awal x402 pay 'https://pubmed.sekgen.xyz/api/v1/trending-subtopics?query=neurofibromatosis+type+2&window=3'
awal x402 pay 'https://pubmed.sekgen.xyz/api/v1/pulse?query=NF2+schwannoma+treatment'

Full research digest ($0.08):

"Give me a comprehensive overview of NF2 schwannomatosis treatment research"

awal x402 pay 'https://pubmed.sekgen.xyz/api/v1/digest?query=NF2+schwannomatosis+treatment&start_year=2022&end_year=2025'

Author profiling ($0.02):

"Who is Scott Plotkin and what's his publication record?"

awal x402 pay 'https://pubmed.sekgen.xyz/api/v1/author?name=Scott+Plotkin'

Discovery mode ($0.10):

"What's interesting happening across neurodegeneration and epigenetics?"

awal x402 pay 'https://pubmed.sekgen.xyz/api/v1/explore?topics=neurodegeneration,epigenetics&limit=5'

Error Handling

• 402 — Payment required. Ensure you're authenticated (awal auth login) with USDC balance.
• 400 — Invalid parameters. Check required fields and constraints (max 50-year range, 2–5 terms for compare).
• 502 — Upstream NCBI error. Retry after a moment.
• 503 — Service temporarily unavailable. Retry after a moment.